About Us

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Center Faculty

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Myles Brown, M.D.

Co-Director

The Myles Brown Lab works on providing a better understanding of the role played by alterations in estrogen signaling in breast cancer. Identification of those factors which are markers for these changes are likely to lead to the development of better diagnostic and predictive tools. More importantly, the identification of the factors which are the critical regulators of the alterations in estrogen signaling will become new therapeutic targets and may lead to the development of improved strategies for the prevention and treatment of breast cancer.
email | website | publications


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Shirley Liu

Co-Director

The Shirley Liu Lab focuses on the design and implementation of statistical and computational algorithms to discover and understand the global mechanisms of gene regulation. By integrating gene expression profiling, transcription factor and chromatin mark ChIP-chip/seq, and genomic sequence and motif analysis, we try to model transcription and epigenetic regulation in biological processes and diseases.
email | website | publications


Ramesh-Shivdasani

Ramesh Shivdasani, M.D.,Ph.D.

The Ramesh Shivdasani Lab focuses on understanding the molecular mechanisms of gut development, in particular the transcriptional control of epithelial differentiation and the intersection between signaling and transcriptional pathways.
email | website | publications


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Kornelia Polyak, M.D., Ph.D.

The Kornelia Polyak Lab focuses on identifying differences between normal and cancerous breast tissue using various technologies, determining their consequences and utilizing them to improve the clinical management of breast cancer patients.
email | website | publications


Matthew Freedman

Matthew Freedman

The Matthew Freedman Lab studies the common risk alleles discovered to date in genome wide association scans which are located in non-protein coding regions. A primary focus of our laboratory is to understand the gene or genes that these variants are acting through. We are adopting a variety of approaches and techniques to develop an approach that will inform our understanding of the functional consequences of risk alleles that are outside of protein coding regions. Another focus of the laboratory is to gain a deeper understanding of the link between the germline and tumor genomes.
email | website | publications